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Partner p53-160 dw manual

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M DW - M DWA - M CMW - M DW 3IN1 - P DWA -

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illustrated parts list model number p53-160dw product - Gardena ...

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Entry whose protein s existence is based on evidence at protein level. Isoform Iso 7 Inhibits isoform 1-mediated apoptosis. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.

Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases.

Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. LincRNA-p21 participates in TPdependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.

Implicated in Notch signaling cross-over. Isoform Iso 2 Enhances the transactivation activity of isoform 1 from some but not all TPinducible promoters.

Isoform Iso 4 Suppresses transactivation activity and impairs growth suppression mediated by isoform 1. The pore-forming pnc peptide of 32 aas from the p53 tumor suppressor protein pnc family. Binds 1 zinc ion per subunit. Activation of NOXA and translocation to mitochondria. Activation of PUMA and translocation to mitochondria.

Click on the download button or simply request the API by using the link below:. TP53 - Function. Gold Only. Protein also known as :. Tumor suppressor p Gene name :. TP53 ;. Family name :. Recommended name TP53 Alternative name P Family p Suggestions for updates are welcome! Please contact us. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise.

Regulation of CAK kinase activity by p Oncogene 17, [Full text: The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. M ] [PubMed: ]. Cell , [Full text: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

Nat Commun 4, [Full text: The function of PML in pdependent apoptosis. Cell Biol. Regulation of human p53 activity and cell localization by alternative splicing. The notch regulator MAML1 interacts with p53 and functions as a coactivator. Cell 25, [Full text: Trim24 targets endogenous p53 for degradation.

The pore-forming pnc peptide of 32 aas from the p53 tumor suppressor protein pnc family 1. It requires the following cofactor. Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. Oncogene 9, [PubMed: ]. Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.

Hsp60 regulation of tumor cell apoptosis. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

EMBO J. Genes Dev. Interacting selectively and non-covalently with copper Cu ions. Oncogene 10, [PubMed: ]. Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery.

The transcribed region might be described as a gene, cistron, or operon. Deacetylation of p53 induces autophagy by suppressing Bmf expression. The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.

In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. Trends Pharmacol. The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.

KEGG pathways. Reactome pathways. Molecular function. Activator KW Definition. Protein that positively regulates either the transcription of one or more genes, or the translation of mRNA. Among those proteins that recognize specific DNA sequences, there are a number of characteristic conserved motifs believed to be essential for specificity.

Repressor KW Definition. Protein which interferes with transcription, usually by binding to specific sites on DNA. Also used for proteins which repress translation. Biological process. Apoptosis KW Definition. Protein involved in apoptotic programmed cell death. Apoptosis is characterized by cell morphological changes, including blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation and chromosomal DNA fragmentation, and eventually death.

Unlike necrosis, apoptosis produces cell fragments, called apoptotic bodies, that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage. In general, apoptosis confers advantages during an organism's life cycle.

Biological rhythms KW Definition. Protein involved in the generation of rhythmic pattern of behaviors or activities, e. Cell cycle KW Definition.

Protein involved in the complex series of events by which the cell duplicates its contents and divides into two. The eukaryotic cell cycle can be divided in four phases termed G1 first gap period , S synthesis, phase during which the DNA is replicated , G2 second gap period and M mitosis. The prokaryotic cell cycle typically involves a period of growth followed by DNA replication, partition of chromosomes, formation of septum and division into two similar or identical daughter cells.

Host-virus interaction KW Definition. Viral or cellular protein involved in a host-virus interaction. Viruses interact with many cellular pathways to achieve their replication cycle.

Entry into the host cell, transport to the viral replication sites or viral exit from the host cell are all steps that require specific interactions between the virus and its host.

Additionally, the evasion from the host immune response requires a lot of viral proteins to associate with and inhibit cellular proteins with antiviral functions. Necrosis KW Definition. Protein involved in necrotic programmed cell death. Necrosis is a form of traumatic cell death that results from acute cellular injury due infection, toxins, trauma, etc. Necrosis is characterized by blebbing, mitochondrial fission, loss of cell membrane integrity and an uncontrolled release of products of cell death into the intracellular space.

This initiates an inflammatory response in the surrounding tissue often resulting is a build-up of dead tissue and cell debris at, or near, the site of the cell death. Transcription KW Definition. Transcription regulation KW Definition. Protein involved in the regulation of the transcription process.

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Motorized instrument for determining the holding or breaking strength of snap fasteners onto garments. To determine the abrasion resistance of textiles, fabric, vinyl, leather, stitched seams, and other materials. For evaluating textile pilling, fabric pilling, woven material pilling or leather abrasion resistance. Features a finished wood handle and 4 brushes identical to those required in the ASTM D fabric pilling test.

The powers inside are also matched by a equally powerful design, enough to make any neighbour jealous. Watch the movie The MTC grass collecting lawn tractor has a narrow 77cm 30" cutting width and is ideal for properties with narrow access points or just gardens where mowing with a walk behind lawnmower is impractical.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Circulation , 05 Feb , 3 : DOI: Free to read.

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This content was uploaded by our users and we assume good faith they have the permission to share this book. If you own the copyright to this book and it is wrongfully on our website, we offer a simple DMCA procedure to remove your content from our site. Start by pressing the button below! OZ, M. While it may be unusual to say that the hours of book research and writing were as much fun as a party, we often felt that they were. Each delivered what they promised, when they promised it. Lisa always made us remember the stronger gender, helped redirect us toward a more upbeat, hip book, and pushed for Ted as our collaborator.

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Entry whose protein s existence is based on evidence at protein level.

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The MD Anderson Manual of Medical Oncology, 3e

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Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection

Ты представляешь, что произойдет, если выйдет из строя система охлаждения ТРАНСТЕКСТА. Бринкерхофф пожал плечами и подошел к окну. - Электроснабжение уже наверняка восстановили.  - Он открыл жалюзи. - Все еще темно? - спросила Мидж. Но Бринкерхофф не ответил, лишившись дара речи. То, что он увидел, невозможно было себе представить.

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Чатрукьян некоторое время смотрел на него, лишившись дара речи, а потом бегом направился прочь из шифровалки. Стратмор повернулся и с удивлением увидел Хейла. Сьюзан поняла, в чем дело: все это время Хейл вел себя тихо, подозрительно тихо, поскольку отлично знал, что нет такой диагностики, в которой использовалась бы цепная мутация, тем более такая, которая занимала ТРАНСТЕКСТ уже восемнадцать часов.

Сделка всей его жизни только что распалась - за каких-то несколько минут. Стратмор продолжал спуск. Сделка отменяется.

Как ты легко можешь себе представить, я был шокирован, впервые наткнувшись на его письмо Северной Дакоте о не поддающемся взлому коде, именуемом Цифровая крепость. Я полагал, что это невозможно. Но всякий раз, когда я перехватывал очередное сообщение, Танкадо был все более и более убедительным. Когда я прочитал, что он использовал линейную мутацию для создания переломного ключа, я понял, что он далеко ушел от нас .

В нем заключено все, что ассоциируется с представлением о молодой католичке: чистота, невинность, природная красота.

Ничего себе капелька. В голове у нее стучало. Повернувшись, она увидела, как за стеной, в шифровалке, Чатрукьян что-то говорит Хейлу. Понятно, домой он так и не ушел и теперь в панике пытается что-то внушить Хейлу. Она понимала, что это больше не имеет значения: Хейл и без того знал все, что можно было знать.

Этот враждебный мир заполняли рабочие мостки, фреоновые трубки и пропасть глубиной 136 футов, на дне которой располагались генераторы питания ТРАНСТЕКСТА… Чатрукьяну страшно не хотелось погружаться в этот мир, да и вставать на пути Стратмора было далеко не безопасно, но долг есть долг.

Завтра они скажут мне спасибо, - подумал он, так и не решив, правильно ли поступает. Набрав полные легкие воздуха, Чатрукьян открыл металлический шкафчик старшего сотрудника лаборатории систем безопасности. На полке с компьютерными деталями, спрятанными за накопителем носителей информации, лежала кружка выпускника Стэнфордского университета и тестер. Не коснувшись краев, он вытащил из нее ключ Медеко. - Поразительно, - пробурчал он, - что сотрудникам лаборатории систем безопасности ничего об этом не известно.

- Я не думал, что он мне поверил. Он был так груб - словно заранее решил, что я лгу. Но я рассказал все, как. Точность - мое правило.

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